This post is going to be a little more scientific and detailed than I normally send, I hope that is ok, let me know what you think about this style of education and if you like it I’ll do more.
When we see people who are exceptionally fit or in incredibly good health in their later years we often blame it on having good genes.
And, that is partially true but the part that is true is the part of the genetic material we all share, it is the end of the chromosome called telomerase. Telomeres control how long and how well we live.
Let me explain.
The discovery of telomerase is a real Christmas miracle. It was on Christmas day that Greider and Blackburn finally proved their theory that an enzyme added telomeric DNA to the ends of chromosomes. That was in 1984, and that enzyme was later named telomerase.
Telomerase is present and active in stem cells, germ cells and cancer cells which is one reason these cells never reach senescence (an endpoint where cells die or no longer divide and thus become inert). Normal cells don’t express telomerase. That gene is suppressed in them. One key to immortality is turning that gene on. Thanks to extensive scientific research, a natural activator TA-65 has been discovered and proven to successfully lengthen telomeres.
But every new discovery is initially feared, then embraced by pioneering spirits, and finally adopted by the hungry masses (or in the case of naturally occurring cures, co-opted by corporations to be patented and turned into expensive controlled medicine since they can’t patent nature).
When it comes to telomeres, many fear turning this gene on in healthy cells is unsafe and risky. Their concern stems from what incorrectly appears to be a similarity or link with cancer.
So, what about cancer? If telomerase is turned on in cancer cells and is the reason a cancer cell continuously replicates, would turning it on in normal cells increase the risk of these cells mutating and becoming cancerous? Specifically is there any evidence that TA-65 causes cancer?
The answer is no and I’ll tell you why.
Stimulating growth of telomeres on normal chromosomes does not cause them to become cancerous because cancer cells are by definition abnormal cells. This bears repeating. It DOES NOT cause normal cells to become cancer cells.
As I explained, cancer cells are abnormal cells. When your genetic material (DNA) becomes damaged or is altered, it mutates and affects normal cell growth and division. Activating telomerase to lengthen telomeres does not alter or damage our DNA. Scientists have turned on the telomerase of normal cells ATTEMPTING to turn these cells into cancer cells and have been repeatedly unsuccessful. So we know that turning on telomerase does not by itself cause cancer.
For the past few decades telomerase research was almost solely focused on creating a “telomerase inhibitor” that could be a potential cure for cancer. Because 80% of all human cancers are immortalized by the turning on of telomerase it’s a logical conclusion that preventing the immortality of cancer cells would slow growth and allow chemotherapies to work more effectively.
I support this research, but when TA-65 was discovered a decade ago and has been shown to be safe and effective as a telomerase activator in healthy cells then the research focus and possibilities expanded. It’s with these new possibilities that I am most intrigued by and signal health and vitality for all long into our “golden years”.
We know that when cells approach senescence (their endpoint), the short telomeres stimulate the chromosome instability, which can cause the mutations that are responsible for creating cancerous cells. If we lengthen the telomeres and extend the life of the cell, we thereby reduce the risk of chromosome rearrangement (where tumor-suppressor genes can be shut off and cancer-causing genes turned on). Telomerase has also been shown to extend the life span of our immune cells, which improves their ability to seek and destroy cancer cells.
According to the American Cancer Society, 78% of all cancers are diagnosed in people 58 years and older. Cancers are more likely to occur when signs of cellular senescence are present and when the immune system begins to be compromised with age and lose its ability to respond to threats. It follows then that extending the period of time before normal cells reach senescence and before immune cells die, would help prevent the creation and spread of cancer in our bodies.
It’s important to note that the unbridled and aggressive way telomerase is activated in cancer cells is also very different from the gentle and mild activation of telomerase in stem-cell and germ-cell lines. TA-65 mimics the natural and gentle activation of telomerase in stem-cells and germ-cells. In 2002, testing and research began with TA-65 and to date there are no studies linking its use to cancer. Rather studies showing its ability to increase the number of “good guys to fight off the bad guys”, gives hope that it will assist our bodies when fighting off cancerous mutations. There is also the possibility that turning telomerase “off” with a telomerase inhibitor (which is where much anti-cancer is now directed) will damage cells that need telomerase activation to be normal anyway including stem cells. Damaging the stem cell line will affect the most rapidly turning over cell types first. This would include the immune system, which is absolutely needed to fight of cancer and infections.
In addition adding TA-65 to human non immortal cancer cell lines, adding TA-65 to pre malignant cells (cells on their way to becoming cancer), adding to-65 to highly cancer prone mice and of course giving TA-65 to people has shown no increases in cancer. As far as prevention that has not yet been thoroughly studied but many of us in the longevity field believe it holds promise for reducing the risk of cancer.
TA-65 is derived from the Astragalus root, a natural compound used and researched for its ability to measurably boost the immune system. Before it was released as a supplement it was studied for effectiveness against various viruses and proved beneficial against HIV to CMV viruses, among others.
These viruses are associated with increased cancer rates, and because of this the question is often posed, “could a telomerase activator actually improve cancer outcomes and maybe even be a cancer preventative?” Geron, the parent company that produces TA-65, is commencing tests and attempting to answer that question.
I believeTA-65 is currently offering cutting edge hope for those pioneering souls who want to explore the boundaries of living fully, healthfully, as long as possible.
A key to remember about living longer is that while the number of years you live is important, the number of years you live fully, with great brain and body function is the real measure of longevity. This is called health span. Most people, scientists, doctors and laymen alike agree, maximizing health span is more important than maximizing life span. Think of it this way, your life can be extended for quite some time with life support but most of us wouldn’t chose to live for months or years on life support.
With TA-65 and Telomerase activation increasing life and health span is now within the reach of almost everyone. I speak with people every day who are exploring ways of extending their health span. If you have specific questions around TA-65 and whether or not it might be effective for you, visit my website for info on contacting me, I’ll be happy to answer your questions.
And please do let me know in the comments below if you like these more technical, educational pieces, if so, I’ll get more of them out right away.
Dr. Dave Woynarowski, MD, was born in the 1950s in the heart of Southeastern Pennsylvania. Raised in a family of doctors and scientists, “Dr. Dave” continued the tradition, graduating from Temple Medical School in the 1980s, after earning his Bachelor of Arts degree at the University of Pennsylvania with a dual major in Biology and English.
After completing his Residency in Internal Medicine, Dr. Dave passed the Internal Medicine Boards and joined his father who had been practicing Family Medicine for three decades.
Dr. Dave later embarked on a worldwide pursuit, researching the best-of-the-best in anti-aging medicine. His exhaustive search has made him one of the foremost authorities is preventative health, anti-aging, and nutritional supplements. For example, he may have more scientific research in his medical library on the health benefits of pharmaceutical grade fish oil than any other person in the world. In addition to study and research, Dr. Dave began the development of a new category of nutritional supplements, formulated from his expertise as a physician, and made from only pharmaceutical-grade ingredients.
"“I traveled the globe for many years, searching the four corners of the earth and left no stone unturned,” says Dr. Dave. “What I found is that most people can be significantly healthier through the use of high quality, properly formulated supplements. The problem was that most of the available products did not use a high enough grade of active ingredients, or did not combine the correct amount of ingredients for a multiple-pronged rather than a single-focus approach to the issue. So I developed Dr. Dave’s Best to meet the need."
Dr. Dave is also co-author of "The Immortality Edge" a book dedicated to teaching everyone about the newest hottest field in anti-aging technology, Telomere Biology and giving practical proven advice for better health and a longer life that everyone can use RIGHT NOW!