Lower PSA with Pomegranate

If you’re a man of a certain age, you’re probably familiar with your PSA score. PSA stands for prostate-specific antigen, a marker for prostate cancer. Many men, along with their doctors, actively look for ways to keep a lid on PSA levels. Now, a clinical trial shows that lowering levels might be as easy as drinking a glass of pomegranate juice.

Several studies have linked a diet high in plant-derived polyphenols—the deeply colored antioxidants in many fruits and vegetables—with a lower risk of developing cancer, including prostate cancer. Because the blood-red juice of pomegranates is especially rich in these compounds, researchers at the David Geffen School of Medicine at the University of California, Los Angeles decided to test it against prostate cancer that had spread beyond the gland—a condition known as metastatic cancer.

The 46 men who participated in the study had had their prostate removed or destroyed, along with their tumors, by radiation. Any residual cancer was being monitored by checking their PSA levels. Because PSA is made by prostate cells as a metric of prostate gland activity, and because these men no longer had intact prostates, the presence of PSA indicated that cancerous prostate cells continued to exist somewhere in the men’s bodies.

The UCLA team calculated that the men’s average doubling time in PSA concentrations—a rough gauge of cancer growth—was 15 months. But after the men began drinking an 8-ounce glass of pomegranate juice each day, the average doubling time more than tripled to 54 months. In nearly one-third of men, their PSA levels actually fell! What’s more, the men’s blood also tended to be less vulnerable to oxidation—a chemical reaction that can damage cells—once they started sipping pomegranate juice.

This isn’t the first study to explore the benefits of pomegranates, but it is the first to use real men. Last fall, researchers at the University of Wisconsin–Madison reported that pomegranate extract had anti-cancer properties in lab studies. They combined cells from an aggressive form of prostate cancer with pomegranate-fruit extract. The higher the concentration of the extract, the greater the inhibition of the cancer cells’ growth.

The researchers also injected human–prostate-cancer cells into lab mice. The cells grew into tumors, but the rate was reduced in animals fed pomegranate extract. The team confirmed the extract’s effect by measuring PSA concentrations in the animals’ blood.

If you have a high risk of prostate cancer, or if you already suffer from the disease, think seriously about trading in your morning orange juice for a glass of ruby red pomegranate. As a bonus, the powerful antioxidants in pomegranate can also benefit heart health, boost your immunity and may even protect against Alzheimer’s disease. Just make sure to choose an unsweetened juice without additives or artificial ingredients.

Want to increase your prostate health even more? Begin by adding foods rich in Vitamin D to your daily diet or begin vitamin D supplementation. Epidemiological studies have shown that there is a link between increased PSA levels and a deficiency in vitamin D. Better yet, emerging research shows that vitamin D can actually reduce prostate cancer cells.

What if you don’t like the taste of pomegranate juice? Try pomegranate extract in capsule form. Look for a supplement made from a whole-food source and take 500 to 1,000 mg. daily. It’s an easy way to do something nice for your overall health—and especially your prostate.



Bell C. Ellagic acid, pomegranate and prostate cancer — a mini review. Journal of Pharmacy and Pharmacology. 2008;60(2):139-144.

Malik A. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proceedings of the National Academy of Sciences USA. 2005;102(41):14813-14818.

Pantuck AJ. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clinical Cancer Research. 2006;12(13):4018-4026.

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Dr. David Blyweiss

Dr. David J. Blyweiss began his medical career as a clinical pharmacist in South Florida prior to earning his medical degree from St. George's University School of Medicine in 1982.

His dual background allowed him to appreciate the relevance of conventional pharmaceutical/surgical based treatments in acute medical conditions, and recognize where these approaches fell short in treating the majority of patients who suffered from the chronic degenerative diseases of "western civilization origin." 

Over the last twenty years, with the nutritional medical knowledge base expanding in the fields of nutrigenomics, protemics, and other related "orthomolecular" disciplines directed towards patients' biochemical individuality, Dr. Blyweiss became an early adherent and experienced practitioner of what would become known as "functional medicine." This knowledge allows him to effectively manage and alleviate the symptoms related to the most "difficult-to-treat" conditions by addressing the underlying causes, allowing the body to heal itself.

Dr. Blyweiss was one of the initial researchers doing the early work on chlorhexidine (Phisohex) while earning his first post graduate degree at Temple University School of Pharmacy. During medical school he worked with the WHO (World Health Organization) in vaccinating children in the islands of the Carribbean. He has traveled much of the world, most recently to Belize, Central America, Gabon, Africa, and Zagreb, Croatia working closely with teams of specialists to identify new plant life and natural products for possible human benefit as well as researchers and their stem cell transplantation teams. He has consulted for and created state-of-the-art nutritional supplements for multiple nutritional companies since 1999. He is currently in private practice in South Florida where he resides with his family.

Dr. David Blyweiss

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  1. says

    I have read other places, and here I think, that PSA is not a good indicator of Prostate Cancer. You can have P. C. with a low PSA score. You can have no P. C. with a high PSA score.
    So, I suppose a digital exam is the surest way to see if there is a “lump”. And by digital, I do not mean “The use of an ELECTRONIC device”. LOL.

    Be well and happy!

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